Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway

This study suggests that NLRP3/GSDMD-mediated pyroptosis plays a crucial role in the pathogenesis of DE and that inhibition of this pathway is a key mechanism by which RMLG alleviates ocular surface inflammation in DE. These findings suggest that RMLG could be a promising therapeutic option for DE, offering new insights into its molecular action and potential clinical application.

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Publication Details

Journal
Journal of Inflammation Research
Published
2024-12-01
DOI
https://doi.org/10.2147/jir.s496231
Citations
5
Primary Topic
Ocular Surface and Contact Lens
Type
article
Field-Weighted Citation Impact
2.71
Controls
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article

Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway

Li Shi, Dan Luo, Zi-meng Wang, Liu-Jiao Li et al.
5 citations
Journal of Inflammation Research
Ocular Surface and Contact Lens
2.71
article

Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway

Li Shi, Dan Luo, Zi-meng Wang, Liu-Jiao Li, Kai Li, Wei-Ping Gao, X.X. Yan, Hongguang Ji
article en
5 citations

Abstract

This study suggests that NLRP3/GSDMD-mediated pyroptosis plays a crucial role in the pathogenesis of DE and that inhibition of this pathway is a key mechanism by which RMLG alleviates ocular surface inflammation in DE. These findings suggest that RMLG could be a promising therapeutic option for DE, offering new insights into its molecular action and potential clinical application.

Journal of Inflammation ResearchVol. Volume 17
Nanjing University of Chinese Medicine (CN), Jiangsu Province Hospital (CN)
Zero hunger
Openalex Percentile: Top 9%
Ocular Surface and Contact Lens
2.71
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