Run-Mu-Ling Granules Mitigate Ocular Surface Inflammatory Injury Associated with Dry Eye by Suppressing the NLRP3/GSDMD-Mediated Pyroptosis Pathway
This study suggests that NLRP3/GSDMD-mediated pyroptosis plays a crucial role in the pathogenesis of DE and that inhibition of this pathway is a key mechanism by which RMLG alleviates ocular surface inflammation in DE. These findings suggest that RMLG could be a promising therapeutic option for DE, offering new insights into its molecular action and potential clinical application.
Authors
- Li Shi (ORCID: https://orcid.org/0000-0002-0644-2884)
- Dan Luo (ORCID: https://orcid.org/0009-0009-4541-7997)
- Zi-meng Wang
- Liu-Jiao Li
- Kai Li (ORCID: https://orcid.org/0000-0003-1664-5439)
- Wei-Ping Gao
- X.X. Yan
- Hongguang Ji
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s496231
- Citations
- 5
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 2.71