Discover Mutational Differences Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma and Search for More Effective Biomarkers for Immunotherapy

We observed distinct mutation patterns and clinical factors between LUAD and LUSC, and noted that patients with TMB≥10 and PD-L1≥50% exhibited enhanced immunotherapy effects. Combining TMB≥10 and PD-L1≥50% proved to be a more effective predictor of immunotherapy efficacy.

Authors

Yanli Shen (ORCID: https://orcid.org/0000-0001-5932-5182)
Yan Yang (ORCID: https://orcid.org/0009-0003-1321-4227)
Yiyi Zhan
Chunling Liu (ORCID: https://orcid.org/0000-0001-9126-6821)
Bo Yu (ORCID: https://orcid.org/0000-0003-4836-9985)
Bing Xu (ORCID: https://orcid.org/0000-0003-0752-2752)
Shiping Lan

Institutions

Xinjiang Medical University (CN)
Tumor Hospital of Xinjiang Medical University (CN)

Publication Details

Journal: Cancer Management and Research
Published: 2024-12-01
DOI: https://doi.org/10.2147/cmar.s491661
Citations: 1
Primary Topic: Lung Cancer Treatments and Mutations
Type: article
Field-Weighted Citation Impact: 0.42

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article

Discover Mutational Differences Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma and Search for More Effective Biomarkers for Immunotherapy

Yanli Shen, Yan Yang, Yiyi Zhan, Chunling Liu et al.

Dec 1, 2024

1 citations

Cancer Management and Research

Lung Cancer Treatments and Mutations

0.42

article

Discover Mutational Differences Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma and Search for More Effective Biomarkers for Immunotherapy

Yanli Shen, Yan Yang, Yiyi Zhan, Chunling Liu, Bo Yu, Bing Xu, Shiping Lan

December 1, 2024article en

1 citations

Abstract

We observed distinct mutation patterns and clinical factors between LUAD and LUSC, and noted that patients with TMB≥10 and PD-L1≥50% exhibited enhanced immunotherapy effects. Combining TMB≥10 and PD-L1≥50% proved to be a more effective predictor of immunotherapy efficacy.

Cancer Management and ResearchVol. Volume 16

Xinjiang Medical University (CN), Tumor Hospital of Xinjiang Medical University (CN)

Good health and well-being

Openalex Percentile: Top 30%

Lung Cancer Treatments and Mutations

0.42

DOI Open Access PDF OpenAlex

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