Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells
Our findings demonstrate that ERβ deficiency exacerbates colitis and enhances ferroptosis in IECs. ERβ positively regulates GPX4 transcription, thereby inhibiting ferroptosis and alleviating colitis. These insights suggest that modulation of ERβ and its regulation of ferroptosis may represent a novel therapeutic strategy for UC.
Authors
- Liangru Zhu (ORCID: https://orcid.org/0000-0002-7372-294X)
- Shuang Li (ORCID: https://orcid.org/0000-0002-9193-0320)
- Yidong Chen (ORCID: https://orcid.org/0000-0002-7866-7628)
- Jiamin Li (ORCID: https://orcid.org/0000-0002-5352-2828)
- Xiaoyu Fu
- Junrong Li (ORCID: https://orcid.org/0000-0002-8292-990X)
- Yiyu Cheng (ORCID: https://orcid.org/0000-0003-1423-162X)
- Xiao‐Peng Zhang (ORCID: https://orcid.org/0000-0001-8170-1236)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s492290
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09