Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora
Our findings elucidate the multifaceted mechanisms underlying BBR's therapeutic efficacy in RA, involving inhibition of the PI3K/AKT pathway, modulation of intestinal flora, and regulation of host metabolites. These insights provide novel perspectives on BBR's role in RA management.
Authors
- Zhou J. Deng (ORCID: https://orcid.org/0000-0003-3762-7790)
- Bocun Li
- Jing Liu (ORCID: https://orcid.org/0009-0008-4541-0712)
- Chuan He (ORCID: https://orcid.org/0000-0003-4319-7424)
- Xiaohong Zhou (ORCID: https://orcid.org/0000-0003-1923-2947)
- Rui Peng (ORCID: https://orcid.org/0009-0003-4775-1987)
Institutions
- Union Hospital (HK)
- Hubei University of Chinese Medicine (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s493892
- Citations
- 5
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 2.24