Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans

Our studies in mice and humans reveal that enhanced function of <i>ITPR1</i>, a well-known movement disorder gene, increases the risk for cardiac arrhythmias.

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Publication Details

Journal
Circulation
Published
2024-12-10
DOI
https://doi.org/10.1161/circulationaha.124.070563
Citations
4
Primary Topic
Receptor Mechanisms and Signaling
Type
article
Field-Weighted Citation Impact
0.94
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article

Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans

Arthur A.M. Wilde, Yongxin Mu, Mads T. Søndergaard, Malene Brohus et al.
4 citations
Circulation
Receptor Mechanisms and Signaling
0.94
article

Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans

Arthur A.M. Wilde, Yongxin Mu, Mads T. Søndergaard, Malene Brohus, Michael T. Overgaard, Josefina Ramos‐Franco, John Paul Estillore, Shitian Cai, S.R. Wayne Chen, Zhenpeng Song, Mingke Ni, Jinjing Yao, Darrell D. Belke, Shubhayan Sanatani, Mette Nyegaard, Michael Fill, Glenn I. Fishman, Jinhong Wei, Alexander Vallmitjana, Wenting Guo, Raúl Benítez, Leif Hove‐Madsen, Palle Duun Rohde, Yanhui Li, Ju Chen, Hai‐Lei Zhu, Ruiwu Wang, Bo Sun, Hui Wang, Shanshan Tian
article en
4 citations

Abstract

Our studies in mice and humans reveal that enhanced function of <i>ITPR1</i>, a well-known movement disorder gene, increases the risk for cardiac arrhythmias.

CirculationVol. 151(12)
Kunming University of Science and Technology (CN), Rush University Medical Center (US), University of British Columbia (CA), Aarhus University (DK), Kunming Medical University (CN), Hospital de Sant Pau (ES), Amsterdam UMC Location University of Amsterdam (NL), University of California San Diego (US), NYU Langone Health (US), Biomedical Research Institute (US), ERN GUARD-Heart (NL), Amsterdam University Medical Centers (NL), Tongji Hospital (CN), Huazhong University of Science and Technology (CN), Aalborg University (DK), WSP (Canada) (CA), Universitat Politècnica de Catalunya (ES)
Good health and well-being
Openalex Percentile: Top 24%
Receptor Mechanisms and Signaling
0.94
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