Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans
Our studies in mice and humans reveal that enhanced function of <i>ITPR1</i>, a well-known movement disorder gene, increases the risk for cardiac arrhythmias.
Authors
- Arthur A.M. Wilde (ORCID: https://orcid.org/0000-0002-0528-0852)
- Yongxin Mu (ORCID: https://orcid.org/0000-0002-5569-5255)
- Mads T. Søndergaard (ORCID: https://orcid.org/0000-0001-6779-5109)
- Malene Brohus (ORCID: https://orcid.org/0000-0001-9247-8551)
- Michael T. Overgaard (ORCID: https://orcid.org/0000-0002-1423-2481)
- Josefina Ramos‐Franco (ORCID: https://orcid.org/0000-0001-5404-9481)
- John Paul Estillore
- Shitian Cai
- S.R. Wayne Chen (ORCID: https://orcid.org/0000-0001-5808-0304)
- Zhenpeng Song (ORCID: https://orcid.org/0000-0003-3084-1356)
- Mingke Ni (ORCID: https://orcid.org/0000-0002-1100-8265)
- Jinjing Yao (ORCID: https://orcid.org/0000-0002-4602-7159)
- Darrell D. Belke (ORCID: https://orcid.org/0009-0002-4418-7201)
- Shubhayan Sanatani (ORCID: https://orcid.org/0000-0001-9296-7400)
- Mette Nyegaard (ORCID: https://orcid.org/0000-0003-4973-8543)
- Michael Fill (ORCID: https://orcid.org/0000-0002-6094-8296)
- Glenn I. Fishman (ORCID: https://orcid.org/0000-0002-2366-8527)
- Jinhong Wei (ORCID: https://orcid.org/0000-0002-5251-9192)
- Alexander Vallmitjana (ORCID: https://orcid.org/0000-0002-7149-9385)
- Wenting Guo (ORCID: https://orcid.org/0000-0002-1370-7764)
- Raúl Benítez (ORCID: https://orcid.org/0000-0002-8782-9406)
- Leif Hove‐Madsen (ORCID: https://orcid.org/0000-0001-5493-3998)
- Palle Duun Rohde (ORCID: https://orcid.org/0000-0003-4347-8656)
- Yanhui Li (ORCID: https://orcid.org/0000-0002-5543-8363)
- Ju Chen (ORCID: https://orcid.org/0000-0001-7674-4776)
- Hai‐Lei Zhu
- Ruiwu Wang (ORCID: https://orcid.org/0000-0003-1564-9219)
- Bo Sun (ORCID: https://orcid.org/0000-0001-7830-132X)
- Hui Wang (ORCID: https://orcid.org/0000-0003-4463-8121)
- Shanshan Tian
Institutions
- Kunming University of Science and Technology (CN)
- Rush University Medical Center (US)
- University of British Columbia (CA)
- Aarhus University (DK)
- Kunming Medical University (CN)
- Hospital de Sant Pau (ES)
- Amsterdam UMC Location University of Amsterdam (NL)
- University of California San Diego (US)
- NYU Langone Health (US)
- Biomedical Research Institute (US)
- ERN GUARD-Heart (NL)
- Amsterdam University Medical Centers (NL)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Aalborg University (DK)
- WSP (Canada) (CA)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Circulation
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1161/circulationaha.124.070563
- Citations
- 4
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.94