Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension
Collectively, we show that FUNDC1-mediated basal mitophagy is critical for endothelial homeostasis, and its disruption instigates PH pathogenesis. Given that similar changes in FUNDC1 and IGFBP2 were observed in PH patients, our findings are of significant clinical relevance and provide novel therapeutic strategies for PH.
Authors
- Qiong Wang (ORCID: https://orcid.org/0000-0003-2018-0726)
- S. Y. Li (ORCID: https://orcid.org/0009-0007-8724-0275)
- Quan Chen (ORCID: https://orcid.org/0000-0001-7539-8728)
- Lin Liu (ORCID: https://orcid.org/0000-0001-9881-6830)
- Chenyue Zhang (ORCID: https://orcid.org/0000-0002-3970-254X)
- Yongle Jing
- Yandong Pei
- Yuli Wu (ORCID: https://orcid.org/0000-0002-5724-9443)
- Hao Zheng (ORCID: https://orcid.org/0000-0002-2821-4153)
- Lin Zhou (ORCID: https://orcid.org/0000-0002-6428-7392)
- Xudong Liao (ORCID: https://orcid.org/0000-0001-8864-0755)
- Cai-Yun Bai
- Gang Hu (ORCID: https://orcid.org/0000-0002-7134-3380)
- Wenxin Hao (ORCID: https://orcid.org/0009-0006-5484-2555)
- Yiqi Weng (ORCID: https://orcid.org/0009-0004-8059-7923)
- Jiangtao Lu
- Yuwei Zhang (ORCID: https://orcid.org/0000-0001-6910-8130)
- Yanjun Li (ORCID: https://orcid.org/0000-0003-3199-8670)
- Guo Chen (ORCID: https://orcid.org/0009-0008-0369-1739)
- Dongfeng Ren (ORCID: https://orcid.org/0009-0006-5010-1645)
- Jiajia Shi (ORCID: https://orcid.org/0009-0000-3395-6859)
- Yujie Cui (ORCID: https://orcid.org/0000-0001-9466-9853)
- Yanping Zhao (ORCID: https://orcid.org/0000-0002-0224-0417)
- Xiaofan Luo
- Lin Zhu (ORCID: https://orcid.org/0009-0004-2233-2855)
- Chengzhi Lu
- Yibing Yin
- Qianyuan Ai (ORCID: https://orcid.org/0009-0005-2176-1612)
Institutions
- Tongji University (CN)
- IHI Corporation (United States) (US)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tongji Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1161/circresaha.124.325156
- Citations
- 17
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.12