C(sp<sup>3</sup>)–H Carbonylative Cyclization of Hydrazones with CO<sub>2</sub>: Synthesis of Pyrazolone Derivatives
A novel method is reported to synthesize various pyrazolones through transition-metal-free and redox-neutral 1°, 2°, or 3° C(sp<sup>3</sup>)-H carbonylative cyclization using 1 atm of CO<sub>2</sub> as a green carbonyl source, featuring good functional group tolerance, a broad substrate scope, facile scalability, and easy product transformation. The utility of this method could be demonstrated by the applications in preparing useful synthetic intermediates and bioactive compounds.
Authors
- Naifu Hu (ORCID: https://orcid.org/0000-0002-2605-0562)
- Youhong Hu (ORCID: https://orcid.org/0000-0003-1770-6272)
- Lefu Lan (ORCID: https://orcid.org/0000-0002-5551-5496)
- Kuoqi Yang
- Jun Ouyang (ORCID: https://orcid.org/0000-0003-3746-7854)
- Huan Liu (ORCID: https://orcid.org/0009-0003-9927-9370)
- Lijun Yin (ORCID: https://orcid.org/0009-0002-5655-999X)
- Kai Wang
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1021/acs.joc.4c02443
- Citations
- 3
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.53
Funders
- Natural Science Foundation of Zhejiang Province