Investigating the therapeutic effects and potential mechanisms of Zuojin Pill in the treatment of gastroesophageal reflux disease
This study provides comprehensive evidence for the therapeutic efficacy of ZJP in GERD, acting through modulation of inflammation, mucosal barrier integrity, and macrophage polarization. Additionally, ZJP downregulated PTGS2 and MMP2 expression and suppressed the activation of MAPK/NF-κB signaling pathways, underscoring its potential as a therapeutic intervention for GERD.
Authors
- Zhiguang Sun (ORCID: https://orcid.org/0000-0003-4990-4425)
- Guoliang Cui (ORCID: https://orcid.org/0000-0001-5559-7957)
- Zhiting Liu (ORCID: https://orcid.org/0000-0002-3261-8695)
- Xiaoman Li (ORCID: https://orcid.org/0000-0002-0658-2414)
- Yuanyuan Wu (ORCID: https://orcid.org/0000-0003-4580-8911)
- Cheng Chang
- Manli Wang (ORCID: https://orcid.org/0000-0002-0679-5997)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jep.2024.119230
- Citations
- 2
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 1.15