Assessment of axonal injury in multiple sclerosis: combined analysis of serum light-chain neurofilaments and diffusion tensor imaging
Combined DTI and serum NFL measurements may enhance the evaluation of axonal injury in MS by providing complementary in vivo and biochemical perspectives. The corresponding changes observed between the modalities support their utility as non-invasive biomarkers reflecting pathophysiological processes and clinical status in MS. Larger validation cohorts are needed to determine the clinical applicability.
Authors
- Iraj Abedi (ORCID: https://orcid.org/0000-0001-8094-0438)
- Mohammadreza Sharifi (ORCID: https://orcid.org/0000-0002-1538-9034)
- Milad Jalilian (ORCID: https://orcid.org/0000-0002-6462-1127)
- Mohammadreza Elhaie (ORCID: https://orcid.org/0009-0007-1186-353X)
Institutions
- Isfahan University of Medical Sciences (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/bmjno-2024-000788
- Citations
- 6
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.55
Funders
- Isfahan University of Medical Sciences