Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia
Our study highlights the pathogenic role of Cflar<sub>R</sub> splicing mediated by neuronal Mef2c, which aggravates neuron necroptosis following stroke with comorbid hyperlipidemia and proposes Cflar<sub>R</sub> splicing as a potential therapeutic target for hyperlipidemic stroke patients.
Authors
- Yunlu Guo (ORCID: https://orcid.org/0000-0001-6073-5947)
- Arthur Liesz (ORCID: https://orcid.org/0000-0002-9069-2594)
- Peiying Li (ORCID: https://orcid.org/0000-0002-5721-9914)
- R.F. Li (ORCID: https://orcid.org/0000-0001-5878-2621)
- Tianchen Huang
- Yueman Zhang (ORCID: https://orcid.org/0000-0002-8187-3350)
- Jieqing Wan (ORCID: https://orcid.org/0000-0003-0118-5038)
- Fengshi Li (ORCID: https://orcid.org/0000-0002-6351-0417)
- Li Gan (ORCID: https://orcid.org/0000-0003-4600-275X)
- Yan Li (ORCID: https://orcid.org/0000-0001-7068-5680)
- Zhenghong Wang (ORCID: https://orcid.org/0009-0001-0442-9539)
- Xiansheng Liu (ORCID: https://orcid.org/0000-0003-0439-6842)
- Jianpo Zhou
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70144
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Science and Technology Commission of Shanghai Municipality
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission