The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via <scp>NF</scp>‐<scp>κB</scp>/<scp>MMP9</scp>
Our study initially identified that Bmal1 regulates the NF-κB /MMP9 pathway to reduce microglial pyroptosis and thereby reduce secondary spinal cord injury, providing a new promising therapeutic target for SCI.
Authors
- Xiao Lu (ORCID: https://orcid.org/0000-0003-3744-2956)
- Feizhou Lu (ORCID: https://orcid.org/0000-0003-2431-0591)
- Guangyu Xu (ORCID: https://orcid.org/0000-0002-4578-1272)
- Xinlei Xia (ORCID: https://orcid.org/0000-0002-3761-5004)
- Zhaoyang Gong (ORCID: https://orcid.org/0000-0002-8633-3353)
- Yuxuan Zhang (ORCID: https://orcid.org/0000-0001-9407-9589)
- Siyang Liu
- Jianyuan Jiang (ORCID: https://orcid.org/0000-0002-1965-2848)
- Fei Zou (ORCID: https://orcid.org/0009-0001-7724-3540)
- Xiaosheng Ma (ORCID: https://orcid.org/0000-0003-2979-0870)
- Dachuan Li (ORCID: https://orcid.org/0000-0002-2028-4245)
- Hongli Wang (ORCID: https://orcid.org/0000-0002-4806-0198)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70130
- Citations
- 10
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China