Effects of Vitamin D Supplementation on Muscle Function in Graves’ Disease Patients

Background: Lack of vitamin D and Graves’ disease are linked to the decrement in quality of life (QoL) and weakening of the muscle groups. The goal of study report was to discover at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients. Method: A single-blinded randomized controlled trial was conducted at King Abdullah Hospital in Mansehra Hospital in Abbottabad. The trial was carried out from January 1, 2021, to January 1, 2022. This study was carried out on 48 participants recruited via the envelop method of simple random sampling technique who had been diagnosed with Graves’ disease. The participants were divided into two groups n=24 in each group. In summation to standard ATD, Groups received either a placebo or received 70 μg (2800 IU) of vitamin D daily. We measured muscular function and isometric strength at baseline, at three, and nine months, whereas QoL was measured at baseline and 9 months. Data was analyzed using SPSS. Paired sample t-test was run for within-group analysis whereas an independent sample t-test was applied for between-group comparison. Statistics were deemed significant when P <0.05. Results: From baseline to the three- and nine-month follow-ups, both groups showed significant gains in hand grip strength, elbow flexion and extension, and knee flexion and extension at 60° and 90° angles (p=0.001). Comparison between group showed an increased mean difference with p <0.001 from baseline to 9 months. For Quality of Life the results were significantly improved in vitamin D group for Goiter Symptoms (p=0.045), Hypothyroid Symptoms (p=0.027), Tiredness (0.032), Emotional Susceptibility (p=0.011), and Social and Work Impact respectively (p=0.034). Conclusion: Vitamin D supplementation appears to enhance muscle function and thyroid-related quality of life (QoL) in patients with Graves’ disease. It significantly improves muscle strength compared to placebo