A DUAL-CIRCUIT CAUSAL MODEL OF BRAIN STIMULATION TARGETS FOR DEPRESSION
This systematic review and meta-analysis aimed to evaluate the efficacy of non-invasive brain stimulation (NIBS) in the treatment of neurodevelopmental disorders (NDDs), focusing on Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), intellectual disorders, learning disorders, motor disorders, and Tourette and tic related disorders across various age groups.Following a pre-registered protocol (PROSPERO: CRD42022384498) and adhering to the PRISMA guidelines, a comprehensive search of five databases (Embase, Central, PsycInfo, PubMed/Medline, and Scopus) was conducted.Out of 23 identified studies, 15 were included in the meta-analysis.Qualitative risk of bias assessment revealed ten studies with low risk, one with high risk, and some concerns for the remaining twelve.In the quantitative analysis, transcranial magnetic stimulation (TMS) demonstrated a statistically significant overall cognitive improvement in ADHD compared to sham (Hedge's g = 0.71, 95% CI: 0.16 to 1.26, p = 0.01), while transcranial direct current stimulation (tDCS) showed a statistically significant overall cognitive improvement in ASD compared to sham (Hedge's g = 0.76, 95% CI: 0.12 to 1.40, p = 0.02).No publication bias was observed in either analysis.Despite promising results, the limited number of studies and concerns about bias underscore the need for further research on NIBS for NDDs.This review emphasizes the significance of standardized methodology and comparable outcome measures in future trials and stresses the value of replicating evidence for potentially effective treatment protocols.
Authors
- Summer Frandsen (ORCID: https://orcid.org/0000-0003-0306-3018)
- Andrea A. Kühn (ORCID: https://orcid.org/0000-0002-4134-9060)
- Mark S. George (ORCID: https://orcid.org/0000-0003-1767-1815)
- Darin D. Dougherty (ORCID: https://orcid.org/0000-0003-4691-4353)
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Andrew Zalesky (ORCID: https://orcid.org/0000-0003-2298-9908)
- Shan H. Siddiqi (ORCID: https://orcid.org/0000-0002-0967-9289)
- Robin Cash
- Andreas Horn (ORCID: https://orcid.org/0000-0002-0695-6025)
- Fidel Vila‐Rodriguez (ORCID: https://orcid.org/0000-0002-8273-8820)
- Jonathan H. Downar (ORCID: https://orcid.org/0000-0002-5140-174X)
- Jordan Grafman (ORCID: https://orcid.org/0000-0001-8645-4457)
- Rob P.W. Rouhl (ORCID: https://orcid.org/0000-0002-0004-1860)
- Álvaro Pascual‐Leone (ORCID: https://orcid.org/0000-0001-8975-0382)
- Yasin Temel (ORCID: https://orcid.org/0000-0002-3589-5604)
- Ki Sueng Choi (ORCID: https://orcid.org/0000-0002-6446-0677)
- Frédéric Schaper (ORCID: https://orcid.org/0000-0001-5487-0923)
- Patricio Riva‐Posse (ORCID: https://orcid.org/0000-0002-5887-0557)
- Stephan F. Taylor (ORCID: https://orcid.org/0000-0001-8777-4292)
- Paul B. Fitzgerald (ORCID: https://orcid.org/0000-0003-4217-8096)
- Friederike Grospietsch
- Kevin A. Johnson
- Daniel M. Blumberger
- Cory Glover
Institutions
- Florida State University (US)
- Brigham and Women's Hospital (US)
- Centre for Addiction and Mental Health (CA)
- Harvard University (US)
- University of British Columbia (CA)
- Emory University (US)
- Medical University of South Carolina (US)
- The University of Melbourne (AU)
- University of Toronto (CA)
- University of Michigan (US)
- Maastricht University Medical Centre (NL)
- Massachusetts General Hospital (US)
- Laboratoire de Neurosciences Cognitives (FR)
- Hebrew SeniorLife (US)
- Ralph H. Johnson VA Medical Center (US)
- Monash University (AU)
- Brandeis University (US)
- Charité - Universitätsmedizin Berlin (DE)
- Universidad del Noreste (MX)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Transcranial magnetic stimulation .
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.transm.2024.100061
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00