TMS PILOT IN EARLY-STAGE ALZHEIMER'S DISEASE USING AN IMAGE-GUIDED MODIFIED ACCELERATED PROTOCOL

pulses of continuous TBS at the pre-supplementary motor area during each session, while the control group will receive sham stimulation.Primary outcomes, including the Gambling Symptom Assessment Scale (G-SAS) and the Visual Analogue Scale (VAS) for craving, were administered at weeks 0, 2, 4, and 8, and the changes between the two groups were compared using generalized estimating equations.Results: A total of 33 patients with gambling disorder were randomly assigned in a 2:1 ratio to the intervention group (21 patients) and the control group (12 patients) on a double-blind basis.They were included in the preliminary analysis on an intention-totreat basis.The VAS scores of the active group decreased more than those of the sham group (active group: 53.3 to 17.9, sham group: 37.5 to 15.3), but the time*group effect did not reach statistical significance (p = 0.13).Conclusions: TBS may decrease craving for gambling in individuals with gambling disorder.Conducting a larger study in the future would be valuable to further test these hypotheses.