5-Aminosalicylic Acid Distribution into the Intestinal Membrane Along the Gastrointestinal Tract After Oral Administration in Rats
The 5-ASA distribution in membranes in the proximal intestine was found to be restricted by the intrinsic regional luminal pH, low solubility, and saturable membrane permeability. Unabsorbed 5-ASA in the proximal intestine was delivered to the distal intestine. The higher the oral dose of 5-ASA, the more 5-ASA may be delivered to the distal intestine due to the restricted absorption in the small intestine.
Authors
- Yuta Goto (ORCID: https://orcid.org/0000-0002-5870-3900)
- Yorinobu Maeda (ORCID: https://orcid.org/0000-0003-2273-6222)
- Yuhzo Hieda
- Teruo Murakami (ORCID: https://orcid.org/0000-0001-6982-0822)
- Satoshi Kawano
- Syoutarou Koga
- Takeshi Goromaru
- F Ohnishi
Institutions
- Fukuyama University (JP)
- Hiroshima International University (JP)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-12-07
- DOI
- https://doi.org/10.3390/pharmaceutics16121567
- Citations
- 8
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.40