Guillain-Barre Syndrome with Acute Lymphoblastic Leukemia: Case Report

Guillain-Barré syndrome (GBS) is a rare complication in children with acute lymphoblastic leukemia (ALL). This case report explores the presentation and management of GBS in a 16-year-old male with a history of ALL, who developed GBS during maintenance therapy. The patient exhibited progressive symmetrical weakness, sensory loss, and autonomic dysfunction. Diagnostic workup, including nerve conduction studies and lumbar puncture, confirmed the diagnosis of GBS. Differentiating GBS from vincristine-induced neuropathy, a common challenge in this population, was crucial for appropriate management. The patient responded well to intravenous immunoglobulin and supportive care. This case highlights the importance of considering GBS in the differential diagnosis of neurological complications in children with ALL and emphasizes the need for prompt diagnosis and treatment.