Preclinical Study of a Dual-Target Molecular Probe Labeled with 68Ga Targeting SSTR2 and FAP
Compared with <sup>68</sup>Ga-labeled FAPI-46 and DOTA-TATE mono-specific tracers, the dual-target tracer [<sup>68</sup>Ga]Ga-TATE-46 improves tumor uptake, extends tumor retention, and enhances pharmacokinetics. It is an effective probe for non-invasive detection of tumors expressing FAP and SSTR2, and it is worth further studying its application in the expression of sstr2 and FAP-related tumors.
Authors
- Hui Wen (ORCID: https://orcid.org/0000-0002-1032-6149)
- Xiaodan Xu (ORCID: https://orcid.org/0000-0001-8338-1600)
- Xiaojun Zhang (ORCID: https://orcid.org/0000-0003-3993-0478)
- Cong Zhang (ORCID: https://orcid.org/0000-0002-0841-5476)
- Jinming Zhang (ORCID: https://orcid.org/0000-0003-1190-3451)
- Huanhuan Liu (ORCID: https://orcid.org/0000-0002-6381-1287)
- Ruimin Wang (ORCID: https://orcid.org/0000-0001-6739-0259)
- Jingfeng Zhang (ORCID: https://orcid.org/0009-0009-5817-8067)
- Guangyu Ma (ORCID: https://orcid.org/0000-0002-8569-7171)
- Yue Pan (ORCID: https://orcid.org/0009-0007-6128-1431)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-12-07
- DOI
- https://doi.org/10.3390/ph17121647
- Citations
- 4
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.13