Calycosin Ameliorates Neuroinflammation via TLR4-Mediated Signal Following Cerebral Ischemia/Reperfusion Injury in vivo and in vitro
These findings suggest that calycosin mitigates cerebral ischemia-reperfusion injury and neuroinflammation by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, thereby providing neuroprotection.
Authors
- Yijie Pan
- Qiguang Wu
- Xiaoya Zhai
- Chong Zhang (ORCID: https://orcid.org/0000-0001-9460-5550)
- Wenbo Wang (ORCID: https://orcid.org/0000-0003-4507-1761)
- Yong Wang (ORCID: https://orcid.org/0000-0001-6602-0491)
- Yuhui Zhang (ORCID: https://orcid.org/0000-0002-4373-1845)
- Jian Chen (ORCID: https://orcid.org/0000-0001-8735-4415)
- Le Cai
- Xin Yang (ORCID: https://orcid.org/0009-0008-6641-7112)
Institutions
- Guilin Medical University (CN)
- Nanxi Mountain Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s480262
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.73