Anti-tumour Activity of 1, 3- Dimethyl Acridones Against Ehrlich Ascites Carcinoma

We report here in vitro and in vivo antitumour activity study of a series of 1,3-dimethyl-N10 substituted acridone derivatives. All the molecules have been designed on the basis of the presence of specific recognition patterns consisting of electron donor, carbons. Chloro groups with precise spatial separation and structural features (lipophilicity, positive charge at neutral pH and presence of aromatic rings). In vitro and in vivo antitumour effects have been demonstrated against EAC cell-lines. Compounds 2,7,8,9,12,13,14 and 15 exhibited good antitumour activity when compared to Vincristine and compound 14 (β-hydroxy ethyl) piperazine derivative with four carbon spacer exhibited good antitumour activity.