High sensitivity detection of influenza virus using polymer-coated microcavity biosensor

Influenza viruses are a major global public health concern because they cause seasonal epidemics and sporadic pandemics. The sensitivity and specificity of viral detection can be improved through recent developments in biosensor technology. The capacity of microcavity biosensors to detect biomolecules, including viruses, in real-time without requiring labels caused interest among them. In this study, we present a novel polymer-coated microcavity biosensor for the high-sensitivity detection of the H1N1 influenza virus. The main microcavity structure of this label-free biosensor is intended to improve sensitivity by optimizing performance characteristics specific to viral samples. The simulation indicates the microcavity resonator’s outstanding sensitivity in H1N1. Our biosensor efficiently detects H1N1 at lower concentrations than conventional diagnostic techniques by utilizing a polymer coating that improves binding affinity and encourages the immobilization of certain antibodies. Using the polymer layer enhances the sensor’s functionality and confers biocompatibility, opening up possible uses in point-of-care environments. The polymer-coated microcavity biosensor, according to our research, is a potential platform for early, sensitive, and quick influenza virus detection, greatly assisting with public health response and monitoring activities.