CAR T cells secreting NGF-neutralizing scFv enhance efficacy in clear cell renal cell carcinoma by relieving immunosuppression through immunosympathectomy
Our results suggest that immunosympathectomy is a novel approach to weaken tumor microenvironment immunosuppression and synergistically enhance CAR T-cell efficacy against solid tumors.
Authors
- Hanmei Xu (ORCID: https://orcid.org/0000-0002-2648-8628)
- Peiwei Yang (ORCID: https://orcid.org/0000-0002-8449-5551)
- Zongke Bai
- Meng Li (ORCID: https://orcid.org/0009-0003-1444-8375)
- Yu Fan (ORCID: https://orcid.org/0000-0003-3409-3471)
- Xi Chen (ORCID: https://orcid.org/0009-0003-4589-3025)
- Lan Wang (ORCID: https://orcid.org/0009-0005-3726-5701)
Institutions
- China Pharmaceutical University (CN)
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009910
- Citations
- 12
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Jiao Tong University
- Fundamental Research Funds for the Central Universities