HDC downregulation induced by chronic stress promotes ovarian cancer progression via the IL-6/STAT3/S100A9 pathway
Chronic stress leads to the downregulation of HDC expression, thereby facilitating the progression of ovarian cancer through the IL-6/STAT3/S100A9 pathway. HIS might serve as a potential molecule for treating the comorbidities of ovarian cancer and depression.
Authors
- Yuanchi Cheng (ORCID: https://orcid.org/0000-0002-8166-4559)
- Zhijun Xiao (ORCID: https://orcid.org/0000-0001-6396-6820)
- Zhicong Chen (ORCID: https://orcid.org/0000-0002-3001-5567)
- Jinming Cao (ORCID: https://orcid.org/0000-0001-5946-4967)
- Feng Xu (ORCID: https://orcid.org/0000-0003-2016-7521)
- Ting Zhou (ORCID: https://orcid.org/0000-0002-8717-9415)
- Zhen Yang (ORCID: https://orcid.org/0000-0003-2105-3630)
- Jingjing Duan (ORCID: https://orcid.org/0000-0002-1092-0666)
Institutions
- Shanghai Sixth People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fphar.2024.1485885
- Citations
- 5
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 1.93