Optimal Dosing Recommendations of Clonidine in Pediatrics Using Physiologically Based Pharmacokinetic Modeling
The pediatric PBPK model of clonidine scaled from the adult PBPK model provided optimal dosing recommendations for clonidine in different pediatric age groups. The pediatric PBPK model described in this study can be extended to other pediatric age groups and routes of administration.
Authors
- Madison Parrot (ORCID: https://orcid.org/0009-0005-3888-2760)
- Venkata Yellepeddi (ORCID: https://orcid.org/0000-0003-3819-9054)
- Catherine M.T. Sherwin (ORCID: https://orcid.org/0000-0002-0844-3207)
- Sharlo Bayless (ORCID: https://orcid.org/0000-0002-5855-8168)
Institutions
- The University of Western Australia (AU)
- Wright State University (US)
- University of Utah (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- The Journal of Pediatric Pharmacology and Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.5863/1551-6776-29.6.636
- Citations
- 1
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 1.11