1,2,3-Triazole-Based Chitosan Derivatives: Recent Aspects, Synthesis and Therapeutic Potential

The integration of 1,2,3-triazole derivatives into medicinal chemistry has emerged as a promising strategy for enhancing the efficacy of therapeutic agents. These compounds demonstrate a broad spectrum of biological effects, such as antifungal, antimicrobial, anti-inflammatory, and anticancer activities.Chitosan, a biocompatible and biodegradable polymer derived from chitin, provides an excellent matrix for the development of functionalized materials. The incorporation of triazole moieties into chitosan and its derivatives through click chemistry enhances their therapeutic potential and expands their applications in biomedical fields. These chitosan-based materials can be engineered for drug delivery systems, improving the solubility and stability of therapeutic agents, as well as for wound healing applications, due to their inherent antimicrobial properties.This review highlights the recent advancements in the application of triazole derivatives in medicinal chemistry and the innovative use of click chemistry in developing chitosan and chitosan derivative-based materials. The synergy between triazole chemistry and chitosan functionality presents exciting opportunities for the design of novel therapeutics and delivery systems, addressing key challenges in contemporary pharmaceutical research