Effecting of Radon Gas on Some Antioxidant and Liver Enzymes of Female Rats

Uranium and its daughters such as radium-226 and radon gas are harmful elements to the human body, it is considered a known carcinogen. Radon exposure can significantly affect the enzymes such as antioxidant enzymes and Liver enzymes. Liver function tests measure how well the liver performs its normal protein-making function and eliminates bilirubin. Other tests on liver function measure the enzymes released by liver cells in response to damage or disease. The present study aimed to determine the effect of radon gas (radium-226 source) on the female rats including a survey change in some antioxidant enzymes (Catalase, Glutathione, LDH, and SOD) and liver enzymes (ALT and AST). The current study included divided the animals to five groups each group contain five animals. The first group rats were no exposed to radon gas which it is as control group. While other groups of rats (4 groups) were exposed to radon gas concentrations 588.51 Bq/m3 of 4 days, 714.62 Bq/m3 of 8 days, 756.66 Bq/m3 of 12 day, and 840.73 Bq/m3 of 16 days, respectively. The result of body weight shows no significance (P>0.05) in the body weight of rats in groups exposed to radon gas in comparison with the control group. In addition, the result of the Catalase, Glutathione, SOD, ALT and AST shows a significant decrease (P<0.05) in groups exposed to radon gas in comparison with the control group, while the LDH is significantly increased (P<0.05) in groups exposed to radon gas in compare with the control group. Therefore, it may be concluded the radon gas at high-time exposure causes effective on antioxidant and liver enzymes in female rats.