Effects of Fractional CO2 Laser Combined with Timolol versus Oxymetazoline in Treatment of Striae Rubra Distensae

Background: Striae Distensae (SD) are a common dermatological condition characterized by dermal scarring due to the rapid stretching of the skin, primarily affecting areas with high adipose tissue. While SD does not pose medical risks, its cosmetic impact often results in psychological distress, necessitating effective treatment options. Fractional CO2 laser therapy has been recognized for its role in promoting collagen remodeling, while topical agents such as Timolol and Oxymetazoline offer additional benefits through vasoconstrictive and anti-angiogenic properties. This review explores the efficacy of Fractional CO2 laser in combination with Timolol and Oxymetazoline for the treatment of Striae Rubra Distensae (SRD). Methods: A comprehensive literature review was conducted on the combined use of Fractional CO2 laser with Timolol and Oxymetazoline in SRD management. The review focused on studies examining histological changes, treatment efficacy, and safety profiles. Clinical outcomes, including improvements in collagen production, vascularity reduction, and overall aesthetic appearance, were evaluated. Conclusion: The combination of Fractional CO2 laser with either Timolol or Oxymetazoline provides synergistic benefits in treating Striae Rubra Distensae. Timolol enhances the reduction of vascularity, while Oxymetazoline improves erythema through vasoconstriction. Both combinations demonstrate effective dermal remodeling and cosmetic improvements in SRD, although individual patient characteristics must guide treatment selection.