Relation between Obesity, Insulin Resistance and T2DM: Review Article

Obesity considered as a serious epidemic and one of the leading global causes of preventable deaths. The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing worldwide. There is a strong link between obesity and insulin resistance (IR), as in more than 80 % of patients with obesity develop IR at specific points in their lifetime, which eventually predisposes to metabolic disorders, including metabolic syndrome, prediabetes and T2DM. Sharing powerful genetic and environmental features in their pathogenesis, obesity amplifies the impact of genetic susceptibility and environmental factors on DM. This study aimed to review relation between obesity, insulin resistance and T2DM.Obesity considered as a serious epidemic and one of the leading global causes of preventable deaths. The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing worldwide. There is a strong link between obesity and insulin resistance (IR), as in more than 80 % of patients with obesity develop IR at specific points in their lifetime, which eventually predisposes to metabolic disorders, including metabolic syndrome, prediabetes and T2DM. Sharing powerful genetic and environmental features in their pathogenesis, obesity amplifies the impact of genetic susceptibility and environmental factors on DM. This study aimed to review relation between obesity, insulin resistance and T2DM.