Obesity and thrombosis: Role of soluble P-selectin

A worldwide issue, obesity is linked to a number of co-morbid conditions, including diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular disorders as stroke , hypertension, coronary and pulmonary diseases. Obesity also raises the risk of developing thrombosis. One of the adhesion molecules that is kept in the platelets' alpha granules and moves about in the plasma in a soluble form is P-selectin. P-selectin surface expression on activated platelets causes platelet–monocyte aggregates to develop, platelet – monocyte aggregates in turn encourages thrombosis and vascular inflammation. Soluble P - selectin (sP - sel) levels are thought to reflect platelet activation, and obese individuals have been found to have higher sP - sel concentrations. This study addresses the relationship between obesity and an increased risk of thrombosis, emphasizing potential factors associated with obesity that may raise the risk of thrombosis, with a particular focus on the function of sP - sel in thrombus development.