Inverse association of fat soluble vitamins with matrix Metalloproteinases ratio of MMP2 and MMP9 in patients of breast cancer

Objective:The study aimed to find association of fat soluble vitamins A, D and E with matrix metalloproteinases MMP-2 and MMP-9 in patients of breast cancer. Methodology: Seventy-five histologically diagnosed females with breast cancer were included in the study. Seventy healthy women were taken as controls. Levels of MMP2, MMP9, fat soluble vitamins (A, D and E) were estimated by standard kit of ELISA. Results: The mean age of patients was 47. Most of the patients had a positive family history of breast cancer (70.6%) and were found to be estrogen receptor positive (86%). Levels of MMP-2, MMP-9 were significantly higher in breast cancer patients than controls. (p value = 0.038 and 0.019). Fat soluble vitamins A, D and E were significantly decreased in patients compared to controls (p value = 0.007,0.038, 0.029 respectively). Anegative Pearson's correlation of MMP2 and MMP-9 was observed with fat soluble vitamins Aand D (r value = -0.25 and -0.15 respectively) and MMP-9 with Vitamin E. (r= -0.35) Conclusion: Impaired expression of MMPs in breast cancer may be an indicator of tumor growth, increase angiogenesis and metastasis. Inverse correlation ratio of MMP-2 and MMP-9 with fat soluble vitamins predict the response to chemotherapy.