Effect of Combination of Alcoholic Extract of Zingiber Officinale (AEZO) and Hydroalcoholic Extract of Brassica Oleracea (HAEBO) on Papain Induced Osteoarthritis in Wistar Rats

Background: The “degenerative joint disease” i.e. Osteoarthritis (OA) is very common nowadays, which affects generally the knee joints. Osteoarthritis occurs in all the synovial joints of the hand, spine, wrist, hip, knee, and ankles. While we are focusing on the current Indian scenario, it was found that the prevalence rate of osteoarthritis ranges from 22-39 percent. Overall, it often affects both males and females after the age of 45. It affects more than 500 million people globally. Age, weight, gender, joint damage, and heredity were additional risk factors for OA. Osteoarthritis causes pain, functional limitation, and deterioration. Herbal remedies can be used to treat such diseases. Methods: The alcoholic extract of Zingiber officinale (AEZO) and the hydroalcoholic extract of Brassica oleracea (HAEBO) in 1:1 proportion were evaluated against papain-induced OA. Evaluation: The paw volume, blood and liver parameters, serum calcium level, histopathology, and radiology were performed once after the treatment of 28 days with the combination. Result: The results of the combination of AEZO and HAEBO-treated groups show that paw volume was reduced but the percentage of paw edema is enhanced. The histological and radiological results also indicated that a mixture of AEZO and HAEBO in 1:1 proportion has anti-osteoarthritic activity in papain-induced osteoarthritis.