Posterior hippocampal sparing in Lewy body disorders with Alzheimer’s copathology: An in vivo MRI study
Relative to LBD/AD-, LBD/AD+ has greater T1w MRI evidence of atrophy in multiple MTL subregions. Atrophy in MTL subregions associates with memory performance and tau pathological load. The observed pattern of atrophy largely follows expectation from AD Braak stages, except for posterior hippocampus. Longitudinal studies are needed to validate the hypothesized spread of neurodegeneration.
Authors
- Ilya M. Nasrallah (ORCID: https://orcid.org/0000-0003-2346-7562)
- Emma Rhodes (ORCID: https://orcid.org/0000-0002-9053-0114)
- Katheryn A Q Cousins (ORCID: https://orcid.org/0000-0003-1879-2766)
- Daniel A. Weintraub (ORCID: https://orcid.org/0000-0003-0633-7168)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Sharon Xiangwen Xie (ORCID: https://orcid.org/0000-0002-7886-4103)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Christopher A. Olm (ORCID: https://orcid.org/0000-0002-4858-2359)
- Jeffrey Phillips
- Hamsanandini Radhakrishnan (ORCID: https://orcid.org/0000-0002-4448-986X)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Jesse Cohen (ORCID: https://orcid.org/0000-0003-2554-5181)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1016/j.nicl.2024.103714
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Alzheimer's Association
- Eli Lilly and Company
- Biogen
- CHDI Foundation
- University of Pennsylvania
- Sage Therapeutics
- Lewy Body Dementia Association
- National Institutes of Health