Possible Biological Heterogeneity of Airway Mucus Plugs in a Patient with Asthma
Biologics including mepolizumab and dupilumab have been reported to improve mucus plugs in patients with asthma; however, their efficacy might be different depending on the clinical characteristics of patients. Present data remind us of the possibility that, if FeNO levels remain high after treatment with anti-IL-5 antibody in asthma patients with mucus plugs, switching to other biologics, including anti-IL-4Rα antibody, might be considered.
Authors
- Masaaki Nanri
- Shinya Kimura (ORCID: https://orcid.org/0000-0003-1717-6208)
- Yuki Kuwahara (ORCID: https://orcid.org/0009-0004-2253-908X)
- Koichiro Takahashi (ORCID: https://orcid.org/0000-0003-0461-5072)
- Hiroki Tashiro (ORCID: https://orcid.org/0000-0001-9699-414X)
- Yuki Kurihara
Institutions
- Saga University (JP)
Publication Details
- Journal
- Journal of Asthma and Allergy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jaa.s499026
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Japan Society for the Promotion of Science