Assessment of Inflammatory Biomarkers and Incident Atrial Fibrillation in Older Adults
Among older adults, IL-6, hs-CRP, white blood cell count, sTNFR1, and sIL-2Rα were positively associated with incident AF, but only IL-6 retained significance on concurrent adjustment. These findings newly document associations for sTNFR1 and sIL-2Rα and lend support to a preeminent role for IL-6 in development of this arrhythmia. The efficacy of IL-6 blockade for AF prevention awaits completion of appropriate clinical trials.
Authors
- Bruce M. Psaty (ORCID: https://orcid.org/0000-0002-7278-2190)
- Nona Sotoodehnia (ORCID: https://orcid.org/0000-0002-2705-6237)
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Susan R. Heckbert (ORCID: https://orcid.org/0000-0002-7100-512X)
- Jorge R. Kizer (ORCID: https://orcid.org/0000-0001-9936-7803)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Gregory M. Marcus (ORCID: https://orcid.org/0000-0001-5197-7696)
- Sanyog G. Shitole (ORCID: https://orcid.org/0000-0002-3831-5118)
- Alex P. Reiner (ORCID: https://orcid.org/0000-0002-1427-4470)
- Jeremy D Walston (ORCID: https://orcid.org/0000-0002-6965-2723)
Institutions
- University of Vermont (US)
- Northwestern University (US)
- Albert Einstein College of Medicine (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- San Francisco VA Health Care System (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1161/jaha.124.035710
- Citations
- 17
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 6.83
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute