Analysis of time-to-positivity data in tuberculosis treatment studies: Identifying a new limit of quantification
Although TTP measurements between 25 days and the diagnostic LOD may be important for diagnostic purposes, TTP values in this range may not contribute meaningfully to its use as a quantitative measure, particularly when assessing treatment response, and may lead to underpowered clinical trials.
Authors
- Anu S. Patel (ORCID: https://orcid.org/0000-0003-0628-668X)
- Pieter Van Brantegem (ORCID: https://orcid.org/0000-0002-0365-5841)
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Patrick P. J. Phillips (ORCID: https://orcid.org/0000-0002-6336-7024)
- Derek J. Sloan (ORCID: https://orcid.org/0000-0002-7888-5449)
- Paolo Denti (ORCID: https://orcid.org/0000-0001-7494-079X)
- Andrew D. McCallum (ORCID: https://orcid.org/0000-0003-0814-3834)
- Suzanne M. Dufault (ORCID: https://orcid.org/0000-0002-6316-6548)
- Geraint Davies (ORCID: https://orcid.org/0000-0002-3819-490X)
Institutions
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- University of Cape Town (ZA)
- University of St Andrews (GB)
- University of California, San Francisco (US)
- Radboud University Medical Center (NL)
- University of California San Francisco Medical Center (US)
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1016/j.ijantimicag.2024.107404
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Bundesministerium für Bildung und Forschung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- University of California, San Francisco
- National Institute of Allergy and Infectious Diseases
- European and Developing Countries Clinical Trials Partnership