Mitigating mitochondrial dysfunction and neuroinflammation by hematoma aspiration in a new surgical model for severe intracerebral hemorrhage
This study established an animal model of severe ICH and provides valuable insights into the complex pathogenesis of severe ICH. The results showed that hematoma aspiration effectively ameliorates mitochondrial dysfunction, oxidative stress, and neuroinflammation, highlighting its potential as a therapeutic intervention.
Authors
- Cheng‐Yoong Pang (ORCID: https://orcid.org/0000-0002-9063-2858)
- Pike-See Cheah (ORCID: https://orcid.org/0000-0003-2181-2502)
- Mikko Airavaara (ORCID: https://orcid.org/0000-0002-2026-1609)
- Sheng‐Tzung Tsai (ORCID: https://orcid.org/0000-0001-6611-9440)
- Andy P. Tsai (ORCID: https://orcid.org/0000-0001-6400-544X)
- Kuan-Yin Tseng
- Hock‐Kean Liew (ORCID: https://orcid.org/0000-0002-5981-4100)
- Po‐Kai Wang (ORCID: https://orcid.org/0000-0003-0321-4699)
- Ming‐Hsiang Shih (ORCID: https://orcid.org/0000-0001-8413-5217)
- Hsin-Yi Huang (ORCID: https://orcid.org/0000-0002-9388-1067)
- Chien-Hui Lee (ORCID: https://orcid.org/0000-0003-1119-1917)
- Yi-Feng Wu
- Wei-Fen Hu
Institutions
- Tri-Service General Hospital (TW)
- University of Helsinki (FI)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Hualien Tzu Chi Medical Center (TW)
- National Defense Medical Center (TW)
- Stanford University (US)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1016/j.expneurol.2024.115098
- Citations
- 5
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation