A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma
Our study highlighted that specific gene expressions and methylation sites significantly influence asthma risk and revealed a potential methylation-to-gene-to-asthma mechanism. This provided pivotal evidence for future targeted functional studies and the development of preventive and treatment strategies.
Authors
- Dan Han (ORCID: https://orcid.org/0000-0001-8710-2218)
- Jiapeng Hu
- Jia Wang (ORCID: https://orcid.org/0000-0001-6973-2566)
- Jinxin Hu
- Dan Qin
Institutions
- Beijing University of Chinese Medicine (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.waojou.2024.101008
- Citations
- 8
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- National Natural Science Foundation of China