Regional brain glucose uptake following gastric bypass surgery during normo- and hypoglycemic clamp: a pilot FDG-PET study
Using dynamic FDG-PET, we show region-specific patterns of changes in glucose utilization following RYGB. In the hypothalamus, glucose uptake during normoglycemia tended to rise after RYGB while it was reduced in cortical regions involved in behavioral control. Following RYGB, the hypothalamus and amygdala, in contrast to other regions, displayed trends of reduced glucose uptake during hypoglycemia. These pilot results highlight the brain effects of RYGB and suggest behavioral and neuroendocrine adaptations which contribute to its antidiabetic effects.
Authors
- Johan Wikström (ORCID: https://orcid.org/0000-0002-9481-6857)
- S Hasan Radhi
- Jan W. Eriksson (ORCID: https://orcid.org/0000-0002-2639-9481)
- Sofia Kvernby (ORCID: https://orcid.org/0000-0001-9093-404X)
- Sven Haller (ORCID: https://orcid.org/0000-0001-7433-0203)
- Argyri Mathioudaki (ORCID: https://orcid.org/0000-0003-0200-0760)
- Magnus Sundbom (ORCID: https://orcid.org/0000-0002-6243-2859)
- Giovanni Fanni (ORCID: https://orcid.org/0000-0002-7920-8909)
- Erika Roman (ORCID: https://orcid.org/0000-0001-5418-8289)
- Mark Lubberink (ORCID: https://orcid.org/0000-0001-8324-7399)
Institutions
- Uppsala University (SE)
- Swedish University of Agricultural Sciences (SE)
- Centre d'Imagerie BioMedicale (CH)
Publication Details
- Journal
- Endocrine
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1007/s12020-024-04127-1
- Citations
- 1
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Novo Nordisk
- Stiftelsen Familjen Ernfors Fond
- Uppsala Universitet
- Agnes och Mac Rudbergs Stiftelse
- P. O. Zetterlings stiftelse
- Svenska Diabetesstiftelsen
- Novo Nordisk Fonden