Current concepts of pustular psoriasis: pathogenesis, diagnosis, treatment

Psoriasis is a chronic skin disease with a variety of clinical forms. Rare variants of pustular psoriasis are associated with the dominance in the pathogenesis of innate and autoinflammatory immune reactions, the leading role in which is played by the cytokine IL-36. Prospects for therapy of generalized pustular psoriasis are associated with the use of inhibitors of the activity of this cytokine. Data on the efficacy of treatment of generalized pustular psoriasis with IL-17A inhibitors are limited, although the drugs are more readily available in practice. A series of clinical cases of successful use of netakimab in the therapy of generalized pustular psoriasis is demonstrated.