Efficacy and safety of risankizumab versus methotrexate in patients with moderate-to-severe plaque psoriasis: results from IMMbrace, a randomized, double-blind, phase 3 study with an open-label extension period in Brazil
Risankizumab demonstrated superior efficacy over methotrexate at week 28; efficacy was maintained, and no new safety findings were observed through week 112.
Authors
- Tânia Ferreira Cestari (ORCID: https://orcid.org/0000-0003-3001-0202)
- Sílvio Alencar Marques (ORCID: https://orcid.org/0000-0002-5512-4700)
- Luiza Keiko Matsuka Oyafuso (ORCID: https://orcid.org/0000-0003-3982-3322)
- Luna Azulay‐Abulafia (ORCID: https://orcid.org/0000-0002-4698-2009)
- Alexandra Song (ORCID: https://orcid.org/0000-0002-8344-6651)
- Caio César Silva de Castro (ORCID: https://orcid.org/0000-0001-9767-5765)
- André Vicente Esteves de Carvalho (ORCID: https://orcid.org/0000-0002-0407-538X)
- Jasmina Kalabic (ORCID: https://orcid.org/0009-0007-4698-1042)
- Ranjeeta Sinvhal (ORCID: https://orcid.org/0009-0003-1950-9181)
- N. P. del Castillo Martín (ORCID: https://orcid.org/0009-0006-9169-8791)
- Ricardo Romiti (ORCID: https://orcid.org/0000-0003-0165-3831)
- Lincoln Zambaldi Fabricio (ORCID: https://orcid.org/0000-0001-9191-1085)
- Tianshuang Wu (ORCID: https://orcid.org/0009-0007-4205-9579)
- Joäo Roberto Antônio (ORCID: https://orcid.org/0000-0002-0268-5934)
- Cacilda da Silva Souza (ORCID: https://orcid.org/0000-0002-8157-7658)
- Vassilis Stakias (ORCID: https://orcid.org/0009-0006-2628-0399)
- Ahmed M. Soliman (ORCID: https://orcid.org/0009-0008-8632-1396)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Ribeirão Preto (BR)
- Faculdade de Medicina de São José do Rio Preto (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- AbbVie (United States) (US)
- Universidade do Estado do Rio de Janeiro (BR)
- Hospital Moinhos de Vento (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Universitário Evangélico de Curitiba (BR)
- AbbVie (Germany) (DE)
- Faculdade de Medicina do ABC (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Anais Brasileiros de Dermatologia
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1016/j.abd.2024.08.002
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AbbVie
- Galderma
- LEO Pharma
- Cilag