Inhibition of Bone Morphogenetic Protein Signaling Prevents Tau Pathology in <scp>iPSC</scp> Derived Neurons and <i>PS19</i> Mice
Our study suggests that the age-related increase in BMP signaling may participate in the onset and progression of tau pathology. Thus, therapeutic interventions that reduce BMP signaling in the aging brain could potentially slow or prevent development of diseases involving tau hyperphosphorylation. ANN NEUROL 2025;97:657-672.
Authors
- Amira Affaneh (ORCID: https://orcid.org/0000-0002-0149-3391)
- Anne K Linden (ORCID: https://orcid.org/0000-0002-9434-6103)
- John A. Kessler (ORCID: https://orcid.org/0000-0003-1948-7712)
- Chian‐Yu Peng (ORCID: https://orcid.org/0000-0003-3407-0894)
- Yung‐Hsu Tsai (ORCID: https://orcid.org/0000-0003-2605-769X)
- Elif Tunc‐Ozcan (ORCID: https://orcid.org/0000-0002-5112-3778)
Institutions
- Northwestern University (US)
- University of New Mexico (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1002/ana.27149
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Northwestern University
- Davee Foundation
- National Institutes of Health
- National Institute on Aging
- National Institute of Arthritis and Musculoskeletal and Skin Diseases