Prophylactic Fetal Creatine Supplementation Improves Post‐Asphyxial <scp>EEG</scp> Recovery and Reduces Seizures in Fetal Sheep: Implications for Hypoxic–Ischemic Encephalopathy
Creatine supplementation reduced post-asphyxial seizures and improved EEG recovery. Improvements in functional recovery with creatine were associated with regional reductions in cell death and astrogliosis. Prophylactic creatine treatment has the potential to mitigate functional indices of HIE in the late gestation fetal brain. ANN NEUROL 2025;97:673-687.
Authors
- Jean Sévigny (ORCID: https://orcid.org/0000-0003-2922-1600)
- Sharmony B. Kelly (ORCID: https://orcid.org/0000-0002-3675-5953)
- Robert Galinsky (ORCID: https://orcid.org/0000-0002-6374-9372)
- David W. Walker (ORCID: https://orcid.org/0000-0002-4958-6140)
- Graeme R. Polglase (ORCID: https://orcid.org/0000-0002-8906-614X)
- Nhi T. Tran (ORCID: https://orcid.org/0000-0002-0396-9760)
- Rodney J. Snow (ORCID: https://orcid.org/0000-0002-4796-6916)
- Stacey J. Ellery (ORCID: https://orcid.org/0000-0003-3769-1960)
- Hui Lü (ORCID: https://orcid.org/0000-0001-9184-2788)
- Madeleine Chatton
Institutions
- Université de Sherbrooke (CA)
- Deakin University (AU)
- Hudson Institute of Medical Research (AU)
- Monash University (AU)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1002/ana.27150
- Citations
- 3
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- RMIT University
- Cerebral Palsy Alliance
- Medical Research Council
- National Health and Medical Research Council