Unravelling the mechanisms causing murepavadin resistance in Pseudomonas aeruginosa: lipopolysaccharide alterations and its consequences
High murepavadin-resistance seems to be linked to <i>lpxL1</i> and <i>lpxL2</i> mutations and lower hexa-acylated lipid-A, corresponding to lower inflammatory induction and higher susceptibility to host-derived AMPs. Although GWAS identified one variant associated with the murepavadin-resistant phenotype, data revealed that there was no unique single genetic event underlying this phenotype. Our study provides insight into the mechanisms underlying murepavadin susceptibility.
Authors
- Miquel B. Ekkelenkamp (ORCID: https://orcid.org/0000-0001-5475-7875)
- Rosa del Campo (ORCID: https://orcid.org/0000-0003-1147-7923)
- Ad C. Fluit (ORCID: https://orcid.org/0000-0003-3432-0021)
- Raquel Barbero-Herranz (ORCID: https://orcid.org/0000-0001-8845-1137)
- Fernando Baquero (ORCID: https://orcid.org/0000-0002-7930-3033)
- Rafael Cantón (ORCID: https://orcid.org/0000-0003-1675-3173)
- Eduardo López‐Collazo (ORCID: https://orcid.org/0000-0003-1957-877X)
- Víctor Fuentes-Valverde (ORCID: https://orcid.org/0000-0002-1827-7003)
- José Avendaño‐Ortiz (ORCID: https://orcid.org/0000-0003-2774-1821)
- José María Hernández Pérez (ORCID: https://orcid.org/0000-0002-2920-212X)
- Francesc J. Márquez-Garrido
- Natalia Bastón-Paz
- María Diez‐Aguilar (ORCID: https://orcid.org/0000-0003-4283-5519)
- Marta Hernández-García (ORCID: https://orcid.org/0000-0003-2857-2572)
- Germán Bou (ORCID: https://orcid.org/0000-0001-8837-0062)
- Miriam Moscoso (ORCID: https://orcid.org/0000-0001-8977-3269)
Institutions
- Instituto de Salud Carlos III (ES)
- University Medical Center Utrecht (NL)
- Hospital La Paz Institute for Health Research (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Hospital Universitario de La Princesa (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3389/fcimb.2024.1446626
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.02
Funders
- Comunidad de Madrid