Pathological features of the differentiation landscape in esophageal squamous cell cancer and their correlations with prognosis
We first time report the mean values of tumor budding invasion margins and tumor budding/10HPF in well, moderately, and poorly differentiated groups for esophageal squamous cell carcinoma. The landscape of well differentiation was depicted with more keratinizing subtypes, smaller tumor budding invasion margins, more Grade 1 tumor budding (0-4 cells), absence of single-cell invasion, larger nuclear diameter (≥5 lymphocytes), higher mitotic counts, and less lymphovascular invasion. The nuclear diameter as independent prognostic factors for prognosis. The findings indicate that pathological features can stratify the differentiation landscape in ESCC patients and offer novel insight into definition of well or moderately differentiation.
Authors
- Yuan Li (ORCID: https://orcid.org/0000-0002-7233-2720)
- Bin Li (ORCID: https://orcid.org/0000-0002-8979-610X)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7242-5292)
- Kuaile Zhao (ORCID: https://orcid.org/0000-0003-1271-2278)
- Zezhou Wang (ORCID: https://orcid.org/0000-0002-8051-9595)
- Longfei Ma (ORCID: https://orcid.org/0000-0003-3419-6403)
- Jiaying Deng (ORCID: https://orcid.org/0000-0002-1744-1203)
- Hongcheng Zhu (ORCID: https://orcid.org/0000-0001-7444-5123)
- Jia-Qing Xiang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Institute of Hematology (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3389/fonc.2024.1442212
- Citations
- 5
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Fudan University