Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy
This study provides compelling evidence for the safety and efficacy of CAR-M therapy in treating pancreatic cancer. The results demonstrate that CAR-M-c-MET significantly suppresses pancreatic cancer progression and enhances the effectiveness of cytotoxic chemotherapy. Remarkably, no discernible side effects occur. Further clinical trials are warranted in human pancreatic cancer patients.
Authors
- Qiaofei Liu (ORCID: https://orcid.org/0000-0001-7148-2850)
- Yun Gao (ORCID: https://orcid.org/0000-0002-2086-5218)
- Xinzhe Yang
- Qing Jiang (ORCID: https://orcid.org/0000-0003-0660-596X)
- Jörg Kleeff (ORCID: https://orcid.org/0000-0003-3432-6669)
- Shanshan Wu (ORCID: https://orcid.org/0000-0002-0201-2297)
- Zhao Yupei
- Xudong Liu (ORCID: https://orcid.org/0000-0002-6893-8842)
- Jiayi Li (ORCID: https://orcid.org/0000-0001-6888-0380)
- Quan Liao (ORCID: https://orcid.org/0000-0001-5999-5602)
- Shangqin Yuan
- Yue Ju
- Huaijin Zheng (ORCID: https://orcid.org/0009-0009-6425-3019)
- Nan Huang (ORCID: https://orcid.org/0009-0008-0944-7315)
Institutions
- Shenyang Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beike Biotechnology (China) (CN)
- Shenyang University of Chemical Technology (CN)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1186/s12943-024-02184-8
- Citations
- 31
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.76
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College