Identification of genetic associations between acute myocardial infarction and non-small cell lung cancer
This study identified eight common signature genes shared between NSCLC and AMI. Validation datasets confirmed the diagnostic value of key hub genes <i>COL1A1</i> and <i>PLAU</i>. These findings suggest that shared hub genes may serve as novel therapeutic targets for patients with both diseases. Ten candidate drugs were predicted, with zoledronic acid showing potential for targeting dual hub genes, offering a promising therapeutic approach for the comorbidity of lung cancer and myocardial infarction.
Authors
- Luxi Wang (ORCID: https://orcid.org/0000-0002-7822-6566)
- Xiaofan Hong
- Hao Zheng (ORCID: https://orcid.org/0000-0002-7834-8010)
- Yijia Zheng (ORCID: https://orcid.org/0000-0003-0405-1633)
- Jie Wang (ORCID: https://orcid.org/0000-0003-2031-7227)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Hangzhou Seventh Peoples Hospital (CN)
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3389/fmolb.2024.1502509
- Citations
- 4
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68