Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis
The hypoxia-related prognostic score (HPS) captures the regulatory influence of TME hypoxia on immune responses, offering valuable insights into its role in tumor progression. HPS holds promise as a prognostic tool and a guide for developing personalized treatment strategies in CRC.
Authors
- Yisong Gao
- Ruikang Tao
- Kaixiong Tao (ORCID: https://orcid.org/0000-0002-7723-6121)
- Gan Mao
- Tianyu Song (ORCID: https://orcid.org/0000-0001-9834-6795)
- Wei Li (ORCID: https://orcid.org/0000-0002-9999-5081)
- Chong Li (ORCID: https://orcid.org/0000-0003-4654-4479)
- Ruizhi Zhang (ORCID: https://orcid.org/0009-0000-8325-111X)
- Suao Liu
- Wenxiang Nie
Institutions
- Union Hospital (HK)
- University of California, Santa Cruz (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3389/fimmu.2024.1425687
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- National Natural Science Foundation of China