Synthesis of Novel Derivatives of 4,6-Diarylpyrimidines and Dihydro-Pyrimidin-4-one and In Silico Screening of Their Anticancer Activity
We synthesized some pyrimidinones, dihydropyrimidinones, and 2,4-diarylsubstituted pyrimidines by combining α-aminoamidines with various saturated carbonyl derivatives and similar compounds. Molecular docking results suggest that certain diaryl derivatives of pyrimidine have a strong binding affinity for PIK3γ. Moreover, diphenyl derivatives of pyrimidine exhibited dual inhibitory activity against PI3K and tubulin, showing promise for the development of next-generation microtubule-targeting agents for use in combination therapies.
Authors
- Alexander V. Kyrychenko (ORCID: https://orcid.org/0000-0002-6223-0990)
- Валентин А. Чебанов (ORCID: https://orcid.org/0000-0001-7564-778X)
- Oleksandr V. Onipko
- Oleksandr V. Buravov (ORCID: https://orcid.org/0009-0008-8433-5524)
- Veronika Stoianova (ORCID: https://orcid.org/0000-0002-5492-8395)
- Eugene S. Gladkov (ORCID: https://orcid.org/0000-0003-3271-5062)
Institutions
- National Academy of Sciences of Ukraine (UA)
- State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine (UA)
- Enamine (Ukraine) (UA)
- V. N. Karazin Kharkiv National University (UA)
Publication Details
- Journal
- Current Organic Synthesis
- Published
- 2024-12-06
- DOI
- https://doi.org/10.2174/0115701794356958241024082646
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.25