miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation
hESC-Exos exhibit significant osteogenic potential by promoting the differentiation of hUCMSCs and enhancing bone regeneration in vivo. This study revealed that the miR-21-5p-YAP1/β-catenin axis is a critical pathway, suggesting that the use of hESC-Exos is a promising therapeutic strategy for bone regeneration and repair.
Authors
- Jiahao Xie (ORCID: https://orcid.org/0000-0002-4632-2959)
- Ziquan Zhao (ORCID: https://orcid.org/0000-0001-5953-1381)
- Jiaqi Chu (ORCID: https://orcid.org/0000-0002-2306-1805)
- Weiqiang Zhan
- Mingzhu Deng (ORCID: https://orcid.org/0000-0003-0258-7354)
- Mingyan Zhao (ORCID: https://orcid.org/0000-0003-4063-8351)
- Xinqia Huang (ORCID: https://orcid.org/0000-0002-3046-897X)
- Zhoutao Chen
- Wei Ye (ORCID: https://orcid.org/0000-0003-1353-8312)
- Xuyang Wu
Institutions
- Guangdong Medical College (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/ijn.s484751
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34