Exploring the complexities of epigenetics in multiple sclerosis: A study involving meta-analysis of DNA methylation profiles, epigenetic drift, and rare epivariations
These findings underscore the role of epigenetic modifications in shaping MS pathology. Furthermore, the study unveiled the exclusive presence of rare epivariations within the MS cases, some of which involved genes previously linked to MS or other autoimmune diseases. This highlights the potential significance of rare genetic aberrations in driving MS susceptibility and progression.
Authors
- Davide Sacco (ORCID: https://orcid.org/0009-0003-4272-3362)
- Giulia Nicole Baldrighi (ORCID: https://orcid.org/0000-0001-8538-4768)
- Lucy Costantino (ORCID: https://orcid.org/0000-0001-6732-8092)
- Davide Gentilini (ORCID: https://orcid.org/0000-0002-8391-0725)
- Rebecca Cavagnola (ORCID: https://orcid.org/0000-0001-6523-0104)
- Luisa Bernardinelli (ORCID: https://orcid.org/0000-0002-7551-6664)
Institutions
- University of Pavia (IT)
- Centro Diagnostico Italiano (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Multiple Sclerosis Journal - Experimental Translational and Clinical
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1177/20552173241296726
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00