Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology
The study identified four immune-related hub genes (TLR2, RETN, HP, and IL7R) in MDD that may impact the diagnosis and treatment of the disorder. By leveraging the GEO database, our findings contribute to the understanding of the relationship between MDD and immunity, presenting potential therapeutic targets.
Authors
- Daming Wu (ORCID: https://orcid.org/0000-0002-2326-9630)
- Yan Ren (ORCID: https://orcid.org/0000-0002-4007-8625)
- Qing Jiang (ORCID: https://orcid.org/0000-0001-9138-1096)
- Shasha Wu
- Jinhui Wang (ORCID: https://orcid.org/0000-0003-1512-827X)
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3389/fpsyt.2024.1485957
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China